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GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.
benzyl (2S,3R)-1-((S)-2-((S)-2-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-3-hydroxy-1-oxobutan-2-ylcarbamate
benzyl (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2 carbonyl)pyrrolidine-2-carboxamide
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
at 20 ℃;
under 2250.23 - 3000.3 Torr;
Large scale;
|
95% |
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
under 2327.23 - 3102.97 Torr;
Industrial scale;
|
43.5% |
Fmoc-Thr-Pro-Pro-ThrNH2
benzyl (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2 carbonyl)pyrrolidine-2-carboxamide
| Conditions | Yield |
|---|---|
|
With
Octanethiol; tert-butylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
|
97% |
The CAS number of GLYX 13 is 117928-94-6.
More information of GLYX 13 117928-94-6 are:
|
CAS Number |
117928-94-6 |
|
Density |
1.37 g/cm3 |
|
Boiling Point |
844.212 °C at 760 mmHg |
|
Flash Point |
464.363 °C |
|
PSA |
179.29000 |
|
LogP |
-1.30530 |
|
Pka |
12.26±0.45(Predicted) |
Synonyms for GLYX 13 117928-94-6:GLYX 13
The chemical formula of GLYX 13 is C18H31N5O6 which containing 18 Carbon atoms,31 Hydrogen atoms,5 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight of GLYX 13 is 413.474.
GLYX 13, also known as Rapastinel, is an investigational drug developed as a novel antidepressant for the treatment of depressive disorders, particularly major depressive disorder. It is a centrally active, intravenously administered amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%). GLYX 13 is characterized by its rapid-acting and long-lasting antidepressant effects, as well as its robust cognitive enhancement capabilities due to its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Relevant articles related to GLYX 13:
|
Article |
Source |
|
Quick Access to High-Purity Peptide Drugs Bradykinin, Leuprolide Analogue, 2(PZ-128), and Rapastinel with Minimal Reagents |
Bisht, Babita,Madhavan, Nandita , p. 17667 - 17672 (2021/12/09) |
|
PROCESSES FOR SYNTHESIS OF DIPYRROLIDINE PEPTIDE COMPOUNDS |
- , (2017/12/27) |
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