Mobile/Wechat/WhatsApp: 18592031892
Email:hiwangqiang@163.com
Quality products make an important contribution to long-term revenue and profitability. Chinese Manufacturer Supply Aicar 2627-69-2 On Stock with Competitive Price
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1,9-dihydro-6H-purin-6-one
AICA riboside
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
for 1h;
Reflux;
|
74% |
|
With
sodium hydroxide;
for 1h;
Heating;
|
73% |
|
9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1,9-dihydro-6H-purin-6-one;
With
sodium hydroxide; water;
for 1h;
Heating / reflux;
With
hydrogenchloride;
In
water;
at 20 ℃;
|
70% |
5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
AICA riboside
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
acetic acid;
for 1.5h;
under 760 Torr;
Ambient temperature;
|
42% |
|
With
hydrogen;
palladium on activated charcoal;
In
water; acetic acid;
at 23 ℃;
for 1h;
under 760 Torr;
|
42% |
The CAS number of AICAR is 2627-69-2.
More information of AICAR 2627-69-2 are:
|
CAS Number |
2627-69-2 |
|
Density |
2.06 g/cm3 |
|
Melting Point |
214-215 °C |
|
Boiling Point |
726.3 °C at 760 mmHg |
|
Flash Point |
393.1 °C |
|
Vapor Pressure |
3.83E-22mmHg at 25°C |
|
Refractive Index |
1.821 |
|
HS CODE |
29349990 |
|
PSA |
156.85000 |
|
LogP |
-1.54280 |
|
Pka |
13.27±0.70(Predicted) |
Synonyms for AICAR 2627-69-2:Imidazole-4-carboxamide,5-amino-1-b-D-ribofuranosyl- (6CI,7CI,8CI);1-Ribosyl-4-carboxamido-5-aminoimidazole;1-b-D-Ribofuranosyl-5-amino-4-imidazolecarboxamide;5-Amino-1-ribosyl-4-imidazolecarboxamide;5-Amino-1-b-D-ribofuranosylimidazole-4-carboxamide;5-Amino-4-imidazolecarboxamide ribofuranoside;5-Amino-4-imidazolecarboxamideriboside;5-Aminoimidazole-4-carboxamide 1-(b-D-ribofuranoside);AIC-Riboside;AICA-Riboside;Acadesine;Arasine;NSC 105823;GP 1-110;
The chemical formula of AICAR is C9H14N4O5 which containing 9 Carbon atoms,14 Hydrogen atoms,4 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of AICAR is 258.234.
AICAR (2627-69-2) activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor.1 Promotes skeletal muscle autophagy via activation of FoxO3a.2 Controls smooth muscle cell hyperproliferation in vascular disease.3 ?Induces osteogenic differentiation in mesenchymal stem cells.4 Inhibits proinflammatory response in glial cells.5 Cell permeable.
InChI:InChI=1/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
Relevant articles related to AICAR:
|
Article |
Source |
|
Solid phase synthesis of nucleobase and ribose modified inosine nucleoside analogues |
Oliviero, Giorgia,Amato, Jussara,D'Errico, Stefano,Borbone, Nicola,Piccialli, Gennaro,Mayol, Luciano , p. 1649 - 1652 (2007) |
|
SAICAR Synthesis method |
- Paragraph 0053; 0061-0062; 0076; 0083-0084; 0098; 0105-0106, (2021/11/06) |
Xi'an Youbo Hui Biotechnology Co., Ltd. is a quality supplier of AICAR. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on AICAR 2627-69-2.
