What is the [LEU5]-ENKEPHALIN?

[LEU5]-ENKEPHALIN is White lyophilized powder, while it's Molecular Formula is C28H37 N5 O7. White lyophilized powder Endogenous opioid neurotransmitter/neuromodulator that is an agonist at ? and δ opioid receptors, localization in brain parallels the localization of δ receptors.

What is the CAS number for [LEU5]-ENKEPHALIN?

The CAS number of [LEU5]-ENKEPHALIN is 58822-25-6.

What is [LEU5]-ENKEPHALIN (58822-25-6) used for?

[LEU5]-ENKEPHALIN is a naturally occurring pentapeptide that functions as an endogenous opioid neurotransmitter and neuromodulator. It acts as an agonist at both μ (mu) and δ (delta) opioid receptors, playing a significant role in the modulation of pain perception, stress response, and reward systems in the brain. The localization of [LEU5]-ENKEPHALIN in the brain closely mirrors the distribution of δ receptors, indicating its importance in various physiological processes.InChI:InChI=1/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1

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(5-Leucine)Enkephalin

CasNo: 58822-25-6
Purity:
Appearance: White lyophilized powder

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Product Details

Cost-effective and customizable (5-Leucine)Enkephalin 58822-25-6 in stock

Molecular Formula:C28H37 N5 O7
Molecular Weight:569.658
Appearance/Colour:White lyophilized powder
Vapor Pressure:0mmHg at 25°C
Melting Point:130-133 °C
Boiling Point:998.8 °C at 760 mmHg
PKA:3.40±0.10(Predicted)
Flash Point:557.8 °C
PSA：199.95000
Density:1.274 g/cm³
LogP:2.10130

[LEU5]-ENKEPHALIN(Cas 58822-25-6) Usage

InChI:InChI=1/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1

58822-25-6 Relevant articles

Cobalt(III)-Mediated Peptide Synthesis. 2. Synthesis of Tetrapeptides and 5>enkephalin

Knighton, D. R.,Harding, D. R. K.,Friar, M. J.,Hancock, W. S.,Reynolds, G. D.,et al.

, p. 7025 - 7026 (1981)

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

Gudmundsson, Olafur S.,Pauletti, Giovanni M.,Wang, Wei,Shan, Daxian,Zhang, Huijuan,Wang, Binghe,Borchardt, Ronald T.

, p. 7 - 15 (1999)

Purpose. To evaluate the cellular permea...

The pivaloylglycol anchor group: A new platform for a photolabile linker in solid-phase synthesis

Peukert, Stefan,Giese, Bernd

, p. 9045 - 9051 (1998)

We have designed a new photolabile linke...

Solid-phase peptide synthesis in water using microwave-assisted heating

Galanis, Athanassios S.,Albericio, Fernando,Grotli, Morten

, p. 4488 - 4491 (2009)

An approach using water as a solvent (co...

Peptide synthesis on fluorous support

Mizuno, Mamoru,Goto, Kohtaro,Miura, Tsuyoshi,Matsuura, Takeshi,Inazu, Toshiyuki

, p. 3425 - 3428 (2004)

New fluorous supports were synthesized a...

Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy

Fujiwara, Suzuko,Hojo, Keiko,Inai, Hoshito,Manabe, Yuki,Tsuda, Yuko

, (2022/01/24)

Seeking a more environmentally balanced ...

Sustainable Peptide Synthesis Enabled by a Transient Protecting Group

Avrutina, Olga,Knauer, Sascha,Koch, Niklas,Kolmar, Harald,Meusinger, Reinhard,Uth, Christina

supporting information, p. 12984 - 12990 (2020/06/01)

The growing interest in synthetic peptid...

TSBP auxiliary group, and liquid-phase total synthesis method of group-assisted enkephalin and derivatives thereof

-

Paragraph 0057-0058; 0114; 0115-0120, (2020/07/02)

The invention relates to a TSBP auxiliar...

Diethylphosphoryl-oxymab (DEPO-B) as a solid coupling reagent for amide bond formation

Kumar, Ashish,Jad, Yahya E.,El-Faham, Ayman,de la Torre, Beatriz G.,Albericio, Fernando

, p. 30 - 33 (2019/05/04)

A new phosphonium based coupling reagent...

58822-25-6 Process route

: (6S,15S,18S)-15-Benzyl-6-(4-hydroxy-benzyl)-18-isobutyl-1,3-dioxa-5,8,11,14,17-pentaaza-cyclononadecane-4,7,10,13,16,19-hexaone

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 124-38-9,18923-20-1
carbon dioxide

: 58822-25-6
Leu-enkephalin

Conditions

Conditions	Yield
rat liver homogenate; In water; dimethyl sulfoxide; at 37 ℃; pH=7.4; Further Variations:; Catalysts; with esterase inhibitor; Enzyme kinetics;

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-40-6
N-Fmoc L-Phe

: 71989-38-3,118488-18-9,204384-67-8
Fmoc-Tyr(tBu)-OH

: 58822-25-6
Leu-enkephalin