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Good factory supply good Pehtagastrin 5534-95-2 We supply high quality PENTAGASTRIN (CAS 5534-95-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
PENTAGASTRIN is , while it's Molecular Formula is C37H49 N7 O9 S. diagnostic agent for gastric secretion disorders
The CAS number of PENTAGASTRIN is 5534-95-2.
More information of PENTAGASTRIN 5534-95-2 are:
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Synonyms |
Alaninamide,N-carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-,N-tert-butyl ester, L- (7CI,8CI);L-Phenylalaninamide,N-[(1,1-dimethylethoxy)carbonyl]-b-alanyl-L-tryptophyl-L-methionyl-L-a-aspartyl-;AY 6608;BOC-b-Ala-Try-Met-Asp-Phe(NH2);ICI 50123;N-(a-Carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-ylpropionamido]-4-(methylthio)butyramido]succinamicacid N-tert-butyl ester;N-Carboxy-b-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamideN-tert-butyl ester;N-t-Butyloxycarbonyl-b-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanineamide;NSC 367746;Pentagastrin;Peptavlon;t-Butoxycarbonyl-b-Ala-Trp-Met-Asp-Phe-NH2; |
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CAS Number |
5534-95-2 |
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Molecular Formula |
C37H49 N7 O9 S |
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Molecular Weight |
767.904 |
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Density |
1.303g/cm3 |
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Melting Point |
229-230° (dec) |
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Boiling Point |
1196.6°Cat760mmHg |
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Flash Point |
677.5°C |
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PSA |
276.21000 |
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LogP |
4.17500 |
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Pka |
4.19±0.10(Predicted) |
Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.
InChI:InChI=1/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t26-,27-,28-,29-/m0/s1
Articles related to PENTAGASTRIN:
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Article |
Source |
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Microwave-assisted solution phase peptide synthesis in neat water |
Mahindra, Amit,Nooney, Karthik,Uraon, Shrikant,Sharma, Krishna K.,Jain, Rahul , p. 16810 - 16816 (2013/09/23) |
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N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives |
- , (2008/06/13) |
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