Tetracosactide

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1.What is the Cosyntropin ?

Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.

Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.

2.What is the CAS number for Cosyntropin ?

The CAS number of Cosyntropin is 16960-16-0.

More information of Cosyntropin 16960-16-0 are:

3.What are another words for Cosyntropin ?

Synonyms for Cosyntropin 16960-16-0:(1-24)a-ACTH;1-24 ACTH (human);4: PN: WO2004045592 SEQID: 3 unclaimed sequence;8: PN: WO0069900 SEQID: 7 unclaimedsequence;ACTH1-24;Actholain;Adrenocorticotropin(1-24);Corticotropin-(1-24);Cortrophin S;HumanACTH (1-24);L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-a-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-;PN: WO9952928 SEQID: 9 claimed protein;Porcine ACTH (1-24);Synacthen;b-Corticotrophin-(1-24)-tetracosapeptide;b1-24-ACTH;b1-24-Tetracosactide;

4.What is the molecular formula of Cosyntropin?

The chemical formula of  Cosyntropin is C136H210N40O31S which containing 136 Carbon atoms,210 Hydrogen atoms,40 Nitrogen atoms,31 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of  Cosyntropin is 2933.46.

5.What is Cosyntropin (16960-16-0) used for?

Cosyntropin is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.

InChI:InChI=1/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(

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